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. intolerance). Ibrutinib is The existing gold common therapy for people with relapsed/refractory ailment, based on the results of several section I-III trials, a hundred and fifteen–119 but This is certainly also shifting for 2 key motives: (i) an increasing proportion of patients now get ibrutinib as frontline therapy; and (ii) a few major contenders have appeared in the last year.
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103,104 Equally trials concluded that early therapy in asymptomatic people was not connected to a prolonged In general survival. Incredibly lately, preliminary final results from a third trial evaluating ibrutinib compared to